主要从事生物信息学与表观遗传学的研究。利用生物信息学策略和分子遗传学技术研究心肌细胞定向分化的表观遗传调节机制和心脏病相关基因的识别；基于生物大数据的复杂疾病的生物标志物识别、分子分型及网络构建，人工智能驱动的多模态数据分析与疾病分子发现。发表SCI论文70余篇，专利5项。主持国家自然科学基金面上项目、上海市科学技术委员会重点项目等15项。
近五年发表论文：
1. Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sanyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng*, Li Li*. LncRNA Foxo6os as a Novel “Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure. Advanced Science.2025. （通讯作者）
2. Lin Q, Sheng J, Zhou C, Xiao T, Meng Y, Lu M, Zhang J, Yan X, Peng L, Cao H, Li L*. LPItabformer: Enhancing generalization in predicting lncRNA-protein interactions via a tabular Transformer. Comput Struct Biotechnol J. 2025 May 29;27:2323-2335. （通讯作者）
3. Yi N, Wang HR, Zhu YP, Xiao T, Lin Q, Liu H, Meng YL, Sun YZ, Lin F, Hu SY, Cao HM, Zhang JF, Peng LY*, Li L*. RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells. Stem Cell Res Ther. 2025 Mar 18;16(1):144. （通讯作者）
4. He S, Li C, Lu M, Lin F, Hu S, Zhang J, Peng L*, Li L*. Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy. J Transl Med. 2025 Jan 6;23(1):17. （通讯作者）
5. Lin F, Liang X, Meng Y, Zhu Y, Li C, Zhou X, Hu S, Yi N, Lin Q, He S, Sun Y, Sheng J, Fan H, Li L*, Peng L*. Unmasking Protein Phosphatase 2A Regulatory Subunit B as a Crucial Factor in the Progression of Dilated Cardiomyopathy.
Biomedicines. 2024 Aug 19;12(8):1887. （通讯作者）
6. Cao W, Liu H, Xu Y, Hu S, Yang Y, Li L*, Peng L*. The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy. Genes Dis. 2023 Nov 25;11(6):101183. （通讯作者）
7. Hu Y, Cao H, Sheng J, Sun Y, Zhu Y, Lin Q, Yi N, He S, Peng L*, Li L*. The functional role of circRNA CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure. J Genet Genomics. 2024 Apr 2:S1673-8527(24)00063-8. （通讯作者）
8. Hu S, Li Z, Liu H, Cao W, Meng Y, Liu C, He S, Lin Q, Shang M, Lin F, Yi N, Wang H, Sachinidis A, Ying Q, Li L*, Peng L*. Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. Int J Mol Med. 2024 Feb;53(2):14. （通讯作者）
9. Huang J, Wang L, Shen Y, Zhang S, Zhou Y, Du J, Ma X, Liu Y, Liang D, Shi D,Ma H, Li L*, Zhang Q*, Chen YH*. CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Nat Commun. 2022 Jul 30;13(1):4433. doi: 10.1038/s41467-022-31996-9. （通讯作者）
10. Shang M, Hu Y, Cao H, Lin Q, Yi N, Zhang J, Gu Y, Yang Y, He S, Lu M, Peng L*,Li L*. Concordant and Heterogeneity of Single-Cell Transcriptome in Cardiac Development of Human and Mouse. Front Genet. 2022 Jun 27;13:892766.（通讯作者）
11. Luo X, Hu Y, Shen J, Liu X, Wang T, Li L*, Li J*. Integrative analysis of DNA methylation and gene expression reveals key molecular signatures in acute myocardial infarction. Clin Epigenetics. 2022 Mar 27;14(1):46.（通讯作者）
12. Liu C, Cui Z, Yan Y, Wu NL, Li L*, Ying Q*, Peng L*. An optimized proliferation system of embryonic stem cells for generating the rat model with large fragment modification. Biochem Biophys Res Commun. 2021 Sep 24;571:8-13.（通讯作者）
13. Xie D, Xiong K, Su X, Wang G, Ji Q, Zou Q, Wang L, Liu Y, Liang D, Xue J, Wang L, Gao X, Gu X, Liu H, He X, Li L, Yang J, Lu Y, Peng L, Chen YH. Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes. Cell Res. 2021 Sep;31(9):951-964.
14. Liang D, Xue J, Geng L, Zhou L, Lv B, Zeng Q, Xiong K, Zhou H, Xie D, Zhang F, Liu J, Liu Y, Li L, Yang J, Xue Z, Chen YH. Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing. Nat Commun. 2021 Jan 12;12(1):287.
15. Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, Ying Q, Li L*, Peng L*. ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem Cells. 2021 Apr;39(4):443-457. （通讯作者）
16. Li Z, Meng Y, Liu C, Liu H, Cao W, Tong C, Lu M, Li L*, Peng L*. Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. Cell Prolif. 2021 Feb;54(2):e12962. （通讯作者）
17. Wu Y, Zhou L, Liu H, Duan R, Zhou H, Zhang F, He X, Lu D, Xiong K, Xiong M, Zhuang J, Liu Y, Li L, Liang D, Chen YH. LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration. Cell Res. 2021 Apr;31(4):450-462.
18. Guo XJ, Qiu XB, Wang J, Guo YH, Yang CX, Li L, Gao RF, Ke ZP, Di RM, Sun YM, Xu YJ, Yang YQ. PRRX1 Loss-of-Function Mutations Underlying Familial Atrial Fibrillation.J Am Heart Assoc. 2021 Dec 7;10(23):e023517. doi: 10.1161/JAHA.121.023517. Epub 2021 Nov 30.
19. Wang Y, Yi N, Hu Y, Zhou X, Jiang H, Lin Q, Chen R, Liu H, Gu Y, Tong C, Lu M, Zhang J, Zhang B, Peng L*, Li L*. Molecular Signatures and Networks of Cardiomyocyte Differentiation in Humans and Mice. Mol Ther Nucleic Acids. 2020 Sep 4;21:696-711. （通讯作者）
20. Li Z, Yi N, Chen R, Meng Y, Wang Y, Liu H, Cao W, Hu Y, Gu Y, Tong C, Lu M, Li L*, Peng L*. miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cell Signal. 2020 Oct;74:109716. （通讯作者）
21. Xie D, Geng L, Xiong K, Zhao T, Wang S, Xue J, Wang C, Wang G, Feng Z, Zhou H, Li Y, Li L, Liu Y, Xue Z, Yang J, Ma H, Liang D, Chen YH. Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase. Circ Res. 2020 Jun 5;126(12):1706-1720.
22. Chen R, He J, Wang Y, Guo Y, Zhang J, Peng L, Wang D, Lin Q, Zhang J, Guo Z*,Li L*. Qualitative transcriptional signatures for evaluating the maturity degree of pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2019 Mar 29;10(1):113. （通讯作者）
